Molecular Mechanism for Wound Repair of Cell Membrane
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 724
Special Issue Editor
Interests: wound repair of cell membrane; cytokinesis; cell migration; cytoskeleton; cell polarity; mechanical force; membrane trafficking; Dictyostelium
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cell membrane functions as a barrier between the extra and intracellular spaces. However, the cell membrane is often injured by external chemical and physical stress. In our bodies, stretches and contractions in muscle tissue and hydrostatic pressure in the cardiovascular system frequently injure the cell membrane. If the cell membrane is wounded, it loses its barrier function, resulting in an influx of undesirable substances into the cell as well as a loss of cytoplasm. However, cells have an ability to rapidly detect and repair the cell membrane if it gets wounded. Defects in cell membrane repair may cause muscular dystrophy, diabetes, vitamin deficiencies, and inflammatory myopathy. Plant cells can also repair the cell membrane. Thus, like DNA repair, wound repair is a physiologically vital phenomenon for living cells. In addition, many methods for introducing extracellular substances into cells, including microinjection and electroporation, rely on cellular wound repair. Research on the wound repair of the cell membrane began in large cells such as amphibian eggs and protozoan amoebas via injury with a fine needle. Recently, cultured animal cells and other various model organisms such as yeast, fruit flies, nematodes, and cellular slime mold have been used via injury with a laser, which enables us to make wound pores of a precise size with accurate timing. The molecular mechanism of wound repair is highly regulated temporally and spatially, involving intracellular signalling, membrane remodelling, membrane trafficking, and cytoskeletal dynamics. Despite recent progress, we have not reached a comprehensive understanding in terms of molecular level. This Special Issue of Cells intends to focus on the wound repair of the cell membrane, mainly in single cells. However, because the multicellular system shares a common feature with single cells, research about wound repair in the multicellular system are also welcome. I hope that this Special Issue of Cells improves our understanding of the wound repair mechanism of the cell membrane.
Prof. Shigehiko Yumura
Guest Editor
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Keywords
- Wound repair
- Wound healing
- Membrane repair
- Membrane resealing
- Multicellular wound repair
- Lesion removal
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