Wnt Signaling in Health and Diseases

Dear Colleagues,

WNT signals are transduced through frizzled receptors and co-receptors to the WNT/β-catenin, WNT/stabilization of proteins (STOP), WNT/planar cell polarity (PCP), WNT/G protein-coupled receptor (GPCR), and WNT/receptor tyrosine kinase (RTK) signaling cascades. WNT signaling cascades cross-talk with the FGF, Notch, Hedgehog, and TGFβ/BMP signaling cascades to regulate embryogenesis, tissue homeostasis, and tumorigenesis. 

Germline mutations in WNT signaling molecules cause hereditary colorectal cancer, bone diseases, exudative vitreoretinopathy, intellectual disability syndrome, and PCP-related diseases. By contrast, somatic alterations in WNT signaling components, such as APC, AXIN2, CTNNB1, RSPO2, RSPO3, and RNF43, occur in colorectal cancer and other types of human cancers.

This Special Issue is calling for reviews and original articles covering translational research on the WNT signaling in cancers as well as con-cancerous diseases, with strong emphasis on the improvement of knowledge for clinical application.

Dr. Masaru Katoh
Guest Editor

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