Tissue-Specific Immune Response

One of the most fascinating features of the immune system is its presence in a wide variety of organs of the body. This characteristic is linked inseparably to the ability of immune cells to adapt to different microenvironments and to specialize in various tasks resulting from their different localization. Innate as well as adaptive immune cell populations have been shown to reside in tissues, where they closely interact with the various cell types that surround them. By doing so, they perform important tasks in the maintenance of tissue homeostasis, as well as under pathological conditions, such as chronic inflammation, autoimmunity, and neoplasms. Since exploiting tissue-specific immune functions holds great potential for targeted immune therapies, it is crucial to understand the peculiarities of tissue-specific immune responses at a mechanistic level.

In recent years, technological advances in the field of imaging as well as single-cell technologies have contributed to our understanding of how tissue-specific immunity is orchestrated at a cellular and molecular level. In this Special Issue of Cells, we would like to call for contributions, which analyze tissue-specific aspects of immunity. This may include, but is not limited to, aspects of tissue residence and tissue-resident immune memory, immunological barrier functions at mucosal surfaces, and compartmentalized immune responses, such as immunity within the CNS. 

Dr. Anja Erika Hauser
Guest Editor

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