Current Trends in Xenobiotic Sensing Nuclear Receptor Research—The Many Facets of PXR and CAR

Dear Colleagues,

The two closely related xenosensing nuclear receptors PXR (pregnane X receptor, NR1I2) and CAR (constitutive androstane receptor, NR1I3) are ligand-modulated master regulators of drug metabolism and transport. By enhancing the capacity of the body to detoxify and eliminate small-molecule drugs, their activation plays a central role in drug–drug interactions leading to adverse reactions or loss of therapeutic efficacy. In addition, PXR and CAR play distinct roles in the regulation of basic cell metabolic pathways, such as glucose and lipid metabolism, as well as in cancer cell proliferation and tumorigenesis. Due to their manifold roles, the development of both agonists and antagonists as potential therapeutics against metabolic diseases and cancer is of great interest.

In order to highlight recent findings in PXR and CAR research, this Topical Collection seeks manuscript submissions for original and review articles from all research disciplines. Topics may cover but are not limited to the discovery and characterization of novel ligands, structural elucidations, investigations on the role of PXR and CAR in cancer development and therapy, assessment of PXR- and/or CAR-modulated metabolic and signaling pathways, or the development of novel techniques and assays for studying receptor function.

We look forward to your contribution.

Dr. Oliver Burk
Prof. Dr. Björn Windshügel
Collection Editors

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