Special Issue "p53 Regulation Mechanisms"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 November 2021.
Interests: p53; p53 target gene; regulation of p53; p53–MDM2 feedback roop; ribosomal proteins; c-Myc; regulation of c-Myc through ribosomal proteins; EMT
Interests: p53 mutations; p53–MDM2 feedback roop; regulation of c-Myc; c-Myc protein stability; histone modifications; immune response; EMT
The tumor suppressor p53 is frequently mutated in various human cancers as it can prevent tumorigenesis by inducing cellular senescence, regulating energy metabolism, blocking metastasis, stopping cell proliferation, and inducing apoptosis, mainly via its transcriptional activity. In response to various stressors, p53 is activated to induce or repress the transcription of numerous target genes important for multiple biological functions. For example, the p53 target gene p21 is involved in p53-dependent cell cycle arrest, while the BH3-only-encoding target genes BBC3 (Puma) and PMAIP1 (Noxa) play key roles in p53-mediated apoptosis. Since activated p53 is generally cytotoxic, it is subjected to tight regulation by MDM2, which is encoded by a transcriptional target gene of p53. Via its N-terminal domain, MDM2 directly binds to the N and C termini of p53 and mediates its ubiquitin-dependent proteolysis, as it possesses intrinsic E3 ubiquitin ligase activity, thus creating a negative feedback loop. The main focus of this Special Issue will be on the broad spectrum of functions of p53 in cancer cells.
We invite all scientists working on p53 to participate in this Special Issue. Original research articles or reviews on all aspects of the molecular and cellular mechanisms modulated by p53 in cancer cells are welcome.
We look forward to your contributions.
Dr. Ji Hoon Jung
Dr. Peng Liao
Dr. Hyemin Lee
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tumor suppressor
- p53 target gene
- novel gene
- cancer therapy