Special Issue "Stem Cell Therapy in Oral and Maxillofacial Region"
Deadline for manuscript submissions: closed (29 February 2020).
Interests: cell fate specification; dental epithelial stem cells; dental genetics; dental pulp stem cells; dental pulp vascular biology; enamel; nanodentistry; nerve growth factor; Notch signaling; odontogenesis; regenerative dentistry; tooth innervation; Wnt signaling
Novel cell-based regenerative therapies for the reconstruction/repair of tissues and organs of the oral and maxillofacial regions such as teeth and bone are very challenging. Repair or reconstruction of teeth and maxilofacial tissues remains a significant clinical problem that requires interdisciplinary approaches in order to be solved. To date, there is not an established and reliable cell-based treatment for the repair of these tissues. Stem cells isolated from teeth or other oral tissues are able to differentiate into osteoblasts, chondrocytes, adipocytes, pericytes, and neuronal cells. The close association of stem cells with neo-vessels in orofacial diseases and their relation to molecular signaling pathways is important in their regulation in order to form dental and maxillofacial-specific cells. The formation of new dental, bone, and epithelial tissues using regenerative therapy approaches would be a major improvement for the treatment of oral and maxillofacial diseases and traumas. These tissues are complex, since they are composed of a variety of cells that are controlled by distinct physical and molecular signals. The importance of these cues has been recognized, and the aim within the tissue engineering and biomaterials communities has been to tailor them to elicit specific biological responses.
Prof. Thimios A. Mitsiadis
Manuscript Submission Information
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- stem cells
- dental pulp stem cells
- hard tissue formation
- signalling molecules
- epithelial stem cells