Regulatory Mechanisms of Skeletal Muscle Stem Cells/Progenitors in Physiological and Pathological Conditions

Dear Colleagues,

Skeletal muscle is an important tissue not only for force production, but also for metabolism. Muscle stem cells/progenitors play essential roles in myogenesis, muscle repair, and homeostasis. In this Special Issue, we have tried to collect edge-cutting studies revealing the functional roles of muscle stem cells/progenitors in the physiological and pathological (muscle atrophy, musclar distrophies, and so on) conditions of the developmental stage and postnatal life. We especially focus on the molecular mechanisms by which the proliferation, differentiation, and self-renewal of muscle stem cells/progenitors are regulated. It is also important to clarify the interaction between myogenic cells and non-myogeic cells, such as fibro-adipogenic precursors (FAPs), which promote muscle regeneration in healthy individuals. Importantly, their dysfunction is related to impaired muscle regeneration, resulting in fibrosis and adipocyte infiltration. Genome-editing, dirent reprogramming, and induced pluripotent stem (iPS) cells are also fascinating research fields that provide new therapeutic strategies for the treatment of muscle diseases. In this Special Issue, we would like to provide readers a place to exchange information and discuss future directions of research on muscle stem cells/progenitors.

Dr. Yuko Miyagoe-Suzuki
Guest Editor

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