Special Issue "MicroRNA and Non-coding RNA"

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editor

Guest Editor
Prof. Dr. Y-h. Taguchi Website E-Mail
Department of Physics, Chuo University, Tokyo 112-8551, Japan
Interests: Bioinformatics; Gene expression analysis; feature selection; tensor decomposition

Special Issue Information

Dear Colleagues,

The canonical functions of miRNAs are known to bind to mRNA and suppress translation. However, more functions of miRNAs, other than binding to mRNAs, are beginning to be reported. One example is that there are many non-coding RNAs, lncRNA and circRNA, that can interact with miRNAs. For example, some ncRNA can act as a miRNA sponge to absorb miRNAs and suppress the functionality of miRNAs. Any studies that focus on the interaction between miRNA and non-coding RNAs are welcomed.

Prof. Y-h. Taguchi
Guest Editor

Manuscript Submission Information

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Keywords

  • miRNA sponge
  • interaction between miRNA and long-non-coding RNA
  • interaction between miRNA and circRNA

Published Papers (1 paper)

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Research

Open AccessArticle
Genome-Wide Identification and Characterization of Long Noncoding RNAs of Brown to White Adipose Tissue Transformation in Goats
Cells 2019, 8(8), 904; https://doi.org/10.3390/cells8080904 - 15 Aug 2019
Abstract
Long noncoding RNAs (lncRNAs) play an important role in the thermogenesis and energy storage of brown adipose tissue (BAT). However, knowledge of the cellular transition from BAT to white adipose tissue (WAT) and the potential role of lncRNAs in goat adipose tissue remains [...] Read more.
Long noncoding RNAs (lncRNAs) play an important role in the thermogenesis and energy storage of brown adipose tissue (BAT). However, knowledge of the cellular transition from BAT to white adipose tissue (WAT) and the potential role of lncRNAs in goat adipose tissue remains largely unknown. In this study, we analyzed the transformation from BAT to WAT using histological and uncoupling protein 1 (UCP1) gene analyses. Brown adipose tissue mainly existed within the goat perirenal fat at 1 day and there was obviously a transition from BAT to WAT from 1 day to 1 year. The RNA libraries constructed from the perirenal adipose tissues of 1 day, 30 days, and 1 year goats were sequenced. A total number of 21,232 lncRNAs from perirenal fat were identified, including 5393 intronic-lncRNAs and 3546 antisense-lncRNAs. Furthermore, a total of 548 differentially expressed lncRNAs were detected across three stages (fold change ≥ 2.0, false discovery rate (FDR) < 0.05), and six lncRNAs were validated by qPCR. Furthermore, trans analysis found lncRNAs that were transcribed close to 890 protein-coding genes. Additionally, a coexpression network suggested that 4519 lncRNAs and 5212 mRNAs were potentially in trans-regulatory relationships (r > 0.95 or r < −0.95). In addition, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses showed that the targeted genes were involved in the biosynthesis of unsaturated fatty acids, fatty acid elongation and metabolism, the citrate cycle, oxidative phosphorylation, the mitochondrial respiratory chain complex, and AMP-activated protein kinase (AMPK) signaling pathways. The present study provides a comprehensive catalog of lncRNAs involved in the transformation from BAT to WAT and provides insight into understanding the role of lncRNAs in goat brown adipogenesis. Full article
(This article belongs to the Special Issue MicroRNA and Non-coding RNA)
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