Induced Pluripotent Stem Cells in Basic and Translational Research

Dear Colleagues,

The ability to turn adult skin, blood, or other types of somatic cells into a pluripotent stem cell has opened new frontiers in basic biology and medical research. An induced pluripotent stem cell (iPSC) is created by reprogramming any cell of the human body into the pluripotent developmental stage. The reprogrammed cells are then able to generate a virtually unlimited number of progeny capable of differentiating into organ-specific specialized functional cells. IPSCs offer a unique research platform for modeling gene variants and monogenic causal genes to characterize gene-associated function and dysfunction, for drug screening, for cell therapy, and for personalized medicine. This Special Issue focuses on recent advances in iPSC basic and translational research, specifically cellular differentiation, the generation of specific lineages, tissue morphogenesis and 3D culture systems, the pathogenesis of diseases, in vitro systems for drug discovery, and the development of innovative therapeutic interventions.

Dr. Marcel M. Daadi
Guest Editor

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