Cellular Signaling Leading to Heart Failure

Dear Colleagues, 

Heart failure (HF) is among the leading causes of death worldwide, with an increased prevalence in the elderly. HF derives from various different diseases, such as hypertension, myocardial infarction, as well as metabolic and genetic disorders. This syndrome is generally preceded by remodeling processes that include myocardial hypertrophy, fibrosis, inflammation, vascular dysfunction, and cardiomyocyte death, leading progressively to cardiac dysfunction and rhythm alterations. Although current therapies targeting ventricular remodeling are effective in reducing morbidity and mortality, mostly in patients with systolic heart failure (HF with reduced ejection fraction, HFrEF), in many instances disease progression continues unabated. No treatment is yet available for patients with HF with preserved ejection fraction (HFpEF),  representing  more than 50% of the prevalent HF cases. Thus, understanding the mechanisms that regulate cardiac remodeling processes might pave the way to important scientific and therapeutic developments in HF.

This Special Issue of Cells is devoted to summarizing current knowledge on the molecular events underlying pathological cardiac remodeling in HFrEF and/or HFpEF. We seek the submission of articles and review papers on topics including, but not limited to, epigenetic mechanisms, membrane receptor and kinase signaling, calcium alterations, mitochondrial dysfunction, remodeling and metabolic dysregulation leading to adverse remodeling and HF, and the identification of new therapeutic targets.

We look forward to your contributions.

Dr. Paula A. Da Costa-Martins
Dr. Frank Lezoualc’h
Guest Editors

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