Novel Aspects of G Protein-Coupled Receptor Signaling

Dear Colleagues,

Members of the GPCR superfamily form the largest group of cell membrane receptors transducing a vast array of signals leading to cellular responses. Their dysfunction is responsible for numerous diseases, including cancer, and GPCRs are one of the main targets of the currently marketed drugs. GPCRs are also one of the most studied proteins in molecular pharmacology. GPCRs possess multiple conformations, signaling possibilities, and biased ligands can induce selective signaling of the receptors. Activated GPCRs are able to initiate waves of signaling events by activating G proteins, binding to β-arrestins, transactivating other receptors, and even inducing signaling with the help of some internalized receptors. The aim of this Special Issue is to provide an overview of the latest findings in the novel aspects of G protein-coupled receptor (GPCR) functions and signaling. This Special Issue of Cells, therefore, invites contributions of review articles and original research papers covering the novel, exciting aspects of GPCRs to provide a better understanding of the complexity of their functions.

Dr. András Balla
Guest Editor

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