New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)

Dear Colleagues,

Pulmonary vascular disease (PVD) encompasses a broad spectrum of various disorders characterized by high resistance and low compliance of pulmonary arteries. These conditions, including pulmonary arterial hypertension (PAH) and several other forms of pulmonary hypertension (PH), can lead to right heart failure and significantly affect the quality of life and longevity of affected individuals.

Recent decades have uncovered novel mechanistic insights into PVDs.  These diseases are primarily attributed to dysregulated cell contraction, proliferation, reduced apoptosis, and altered cell signaling in pulmonary vascular cells, such as endothelial cells and smooth muscle cells. New research has elucidated important features like reactive oxygen species formation and the role of inflammation that contribute to the vascular contraction and remodeling linked with PVDs.  The emerging role of transcription factors, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) in modulating gene expression patterns has also opened new research avenues into the pathogenesis of PVD.

These novel mechanistic insights have sparked interest in developing targeted treatments, such as vasodilators, prostacyclin agonists, and inhibitors of particular signaling pathways and cellular processes. The advancements provide hope that next-generation drugs could target specific molecular mechanisms to effectively control disease progression.

This Special Issue looks forward to collecting the latest research on PVDs. We encourage you to contribute to this Special Issue of Cells by submitting a research article or a review.

Prof. Dr. Yong-Xiao Wang
Guest Editor

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