Exosomes as Mediators of Immunosuppression in Tumor and Chronic Inflammatory Microenvironments
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (10 March 2022) | Viewed by 48814
Special Issue Editors
Interests: tumor microenvironment; immunology; exosome; extracellular vesicles; T cell immunity
Interests: cancer immunology; immunotherapy; exosomes; tumor microenvironment; T cell immunity; chronic inflammation; immunogenicity of protein therapeutics; oral tolerance
Special Issue Information
Dear Colleagues,
Small extracellular vesicles ranging in size from 30-150 nm and surrounded by a lipid bilayer, known as exosomes, are present in the microenvironment of tumor and chronic inflammatory tissues. These tumor-associated exosomes are heterogeneous and are derived from both normal and neoplastic cells. Exosomes have been reported to serve a plethora of different functions in regulating health and disease, including the progression of tumors and chronic inflammatory conditions such as rheumatoid arthritis and chronic rhinosinusitis by inducing immunosuppression. The immunosuppressive nature of these exosomes has been ascribed to their constituents, which include lipids (e.g. phosphatidylserine, ganglioside GD3), proteins (e.g. PD-L1, IL-10) and nucleic acids (e.g. miR-24-3p). Some of these immunosuppressive molecules have been identified as being present on the surface of exosomes (e.g. phosphatidylserine) while others are part of the exosomal cargo (e.g. IL-10).
The aim of this special issue is to present and review in vitro as well as in vivo data that identify the presence of immunosuppressive exosomes in tumors and chronic inflammatory microenvironments, establish mechanisms of immunosuppression, and explore the viability of strategies for targeting these vesicles as means of therapeutic intervention. We invite original contributions as well as review articles that provide new insights to help us better understand the fascinating world of these nano-sized vesicles.
Prof. Dr. Richard B. Bankert
Dr. Gautam N. Shenoy
Guest Editors
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Keywords
- Exosomes
- Extracellular vesicles
- Tumor microenvironment
- Chronic inflammation
- T cell responses
- Immunosuppression
- Therapeutic targets
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