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GPCR-Hippo Signaling in Cancer

Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
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Author to whom correspondence should be addressed.
Cells 2019, 8(5), 426; https://doi.org/10.3390/cells8050426
Received: 29 March 2019 / Revised: 3 May 2019 / Accepted: 7 May 2019 / Published: 8 May 2019
(This article belongs to the Special Issue Disease and the Hippo Pathway: Cellular and Molecular Mechanisms)
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Abstract

The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies have identified a wide range of upstream regulators of the Hippo pathway, including mechanical cues and ligands of G protein-coupled receptors (GPCRs). Through the activation related G proteins and possibly rearrangements of actin cytoskeleton, GPCR signaling can potently modulate the phosphorylation states and activity of YAP and TAZ, two homologous oncogenic transcriptional co-activators, and major effectors of the Hippo pathway. Herein, we summarize the network, regulation, and functions of GPCR-Hippo signaling, and we will also discuss potential anti-cancer therapies targeting GPCR-YAP signaling.
Keywords: G protein-coupled receptor; GPCR; Hippo pathway; YAP/TAZ; signal transduction; cancer; tumorigenesis; anti-cancer therapy G protein-coupled receptor; GPCR; Hippo pathway; YAP/TAZ; signal transduction; cancer; tumorigenesis; anti-cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Luo, J.; Yu, F.-X. GPCR-Hippo Signaling in Cancer. Cells 2019, 8, 426.

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