GPCR-Hippo Signaling in Cancer
AbstractThe Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies have identified a wide range of upstream regulators of the Hippo pathway, including mechanical cues and ligands of G protein-coupled receptors (GPCRs). Through the activation related G proteins and possibly rearrangements of actin cytoskeleton, GPCR signaling can potently modulate the phosphorylation states and activity of YAP and TAZ, two homologous oncogenic transcriptional co-activators, and major effectors of the Hippo pathway. Herein, we summarize the network, regulation, and functions of GPCR-Hippo signaling, and we will also discuss potential anti-cancer therapies targeting GPCR-YAP signaling.
Share & Cite This Article
Luo, J.; Yu, F.-X. GPCR-Hippo Signaling in Cancer. Cells 2019, 8, 426.
Luo J, Yu F-X. GPCR-Hippo Signaling in Cancer. Cells. 2019; 8(5):426.Chicago/Turabian Style
Luo, Jiaqian; Yu, Fa-Xing. 2019. "GPCR-Hippo Signaling in Cancer." Cells 8, no. 5: 426.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.