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MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
Open AccessFeature PaperEditor’s ChoiceReview

Regulation of TEAD Transcription Factors in Cancer Biology

1
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea
2
Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 50612, Korea
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(6), 600; https://doi.org/10.3390/cells8060600
Received: 20 April 2019 / Revised: 10 June 2019 / Accepted: 11 June 2019 / Published: 17 June 2019
(This article belongs to the Special Issue Disease and the Hippo Pathway: Cellular and Molecular Mechanisms)
Transcriptional enhanced associate domain (TEAD) transcription factors play important roles during development, cell proliferation, regeneration, and tissue homeostasis. TEAD integrates with and coordinates various signal transduction pathways including Hippo, Wnt, transforming growth factor beta (TGFβ), and epidermal growth factor receptor (EGFR) pathways. TEAD deregulation affects well-established cancer genes such as KRAS, BRAF, LKB1, NF2, and MYC, and its transcriptional output plays an important role in tumor progression, metastasis, cancer metabolism, immunity, and drug resistance. To date, TEADs have been recognized to be key transcription factors of the Hippo pathway. Therefore, most studies are focused on the Hippo kinases and YAP/TAZ, whereas the Hippo-dependent and Hippo-independent regulators and regulations governing TEAD only emerged recently. Deregulation of the TEAD transcriptional output plays important roles in tumor progression and serves as a prognostic biomarker due to high correlation with clinicopathological parameters in human malignancies. In addition, discovering the molecular mechanisms of TEAD, such as post-translational modifications and nucleocytoplasmic shuttling, represents an important means of modulating TEAD transcriptional activity. Collectively, this review highlights the role of TEAD in multistep-tumorigenesis by interacting with upstream oncogenic signaling pathways and controlling downstream target genes, which provides unprecedented insight and rationale into developing TEAD-targeted anticancer therapeutics. View Full-Text
Keywords: TEAD; Hippo pathway; cancer; stem cell TEAD; Hippo pathway; cancer; stem cell
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MDPI and ACS Style

Huh, H.D.; Kim, D.H.; Jeong, H.-S.; Park, H.W. Regulation of TEAD Transcription Factors in Cancer Biology. Cells 2019, 8, 600. https://doi.org/10.3390/cells8060600

AMA Style

Huh HD, Kim DH, Jeong H-S, Park HW. Regulation of TEAD Transcription Factors in Cancer Biology. Cells. 2019; 8(6):600. https://doi.org/10.3390/cells8060600

Chicago/Turabian Style

Huh, Hyunbin D.; Kim, Dong H.; Jeong, Han-Sol; Park, Hyun W. 2019. "Regulation of TEAD Transcription Factors in Cancer Biology" Cells 8, no. 6: 600. https://doi.org/10.3390/cells8060600

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