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Hippo Pathway in Mammalian Adaptive Immune System

1
Department of Molecular Enzymology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
2
Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
3
Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Kawaguchi 332-0012, Japan
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 398; https://doi.org/10.3390/cells8050398
Received: 7 April 2019 / Revised: 26 April 2019 / Accepted: 28 April 2019 / Published: 30 April 2019
(This article belongs to the Special Issue Disease and the Hippo Pathway: Cellular and Molecular Mechanisms)
The Hippo pathway was originally identified as an evolutionarily-conserved signaling mechanism that contributes to the control of organ size. It was then rapidly expanded as a key pathway in the regulation of tissue development, regeneration, and cancer pathogenesis. The increasing amount of evidence in recent years has also connected this pathway to the regulation of innate and adaptive immune responses. Notably, the Hippo pathway has been revealed to play a pivotal role in adaptive immune cell lineages, as represented by the patients with T- and B-cell lymphopenia exhibiting defective expressions of the pathway component. The complex regulatory mechanisms of and by the Hippo pathway have also been evident as alternative signal transductions are employed in some immune cell types. In this review article, we summarize the current understanding of the emerging roles of the Hippo pathway in adaptive immune cell development and differentiation. We also highlight the recent findings concerning the dual functions of the Hippo pathway in autoimmunity and anti-cancer immune responses and discuss the key open questions in the interplay between the Hippo pathway and the mammalian immune system. View Full-Text
Keywords: Hippo pathway; innate immunity; adaptive immunity; cancer immunity; autoimmunity; YAP (yes-associated protein); TAZ (transcriptional co-activator with PDZ-binding motif); LATS (large tumor suppressor kinase); MST (mammalian STE20-like protein kinase) Hippo pathway; innate immunity; adaptive immunity; cancer immunity; autoimmunity; YAP (yes-associated protein); TAZ (transcriptional co-activator with PDZ-binding motif); LATS (large tumor suppressor kinase); MST (mammalian STE20-like protein kinase)
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Yamauchi, T.; Moroishi, T. Hippo Pathway in Mammalian Adaptive Immune System. Cells 2019, 8, 398.

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