Hippo Pathway in Mammalian Adaptive Immune System
Abstract
1. Introduction
2. Hippo Pathway in Adaptive Immune Cell Lineage and Functions
2.1. Clinical Significance of the Hippo Pathway in Adaptive Immunity
2.2. MST1/2 in T Cell Development
2.3. Hippo Signaling in Effector T Cell Differentiation and Functions
2.3.1. Hippo Pathway in Cytotoxic CD8+ T Cell Differentiation and Functions
2.3.2. Hippo Pathway in Helper CD4+ Th17 and Treg Cells
2.4. Critical Roles of MST1 in B cell Development and Functions
2.5. MST1/2 in Dendritic Cell Functions
2.6. Hippo Pathway in Macrophages
3. Dual Functions of the Intracellular Hippo Signaling in Regulating Immune Responses
3.1. Immunostimulatory Role of the Hippo Pathway in Non-Immune Cells
3.2. Immunosuppressive Role of the Hippo Pathway in Non-Immune Cells
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Yamauchi, T.; Moroishi, T. Hippo Pathway in Mammalian Adaptive Immune System. Cells 2019, 8, 398. https://doi.org/10.3390/cells8050398
Yamauchi T, Moroishi T. Hippo Pathway in Mammalian Adaptive Immune System. Cells. 2019; 8(5):398. https://doi.org/10.3390/cells8050398
Chicago/Turabian StyleYamauchi, Takayoshi, and Toshiro Moroishi. 2019. "Hippo Pathway in Mammalian Adaptive Immune System" Cells 8, no. 5: 398. https://doi.org/10.3390/cells8050398
APA StyleYamauchi, T., & Moroishi, T. (2019). Hippo Pathway in Mammalian Adaptive Immune System. Cells, 8(5), 398. https://doi.org/10.3390/cells8050398