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The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry

Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada
Department of Biology, Queen’s University, Kingston, ON K7L 3N6, Canada
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 407;
Received: 29 March 2019 / Revised: 29 April 2019 / Accepted: 30 April 2019 / Published: 1 May 2019
(This article belongs to the Special Issue Disease and the Hippo Pathway: Cellular and Molecular Mechanisms)
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Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a physiological process that begins in utero and continues throughout life in both good health and disease. Understanding the underlying mechanism in angiogenesis could uncover a new therapeutic approach in pathological angiogenesis. Since its discovery, the Hippo signaling pathway has emerged as a key player in controlling organ size and tissue homeostasis. Recently, new studies have discovered that Hippo and two of its main effectors, Yes-associated protein (YAP) and its paralog transcription activator with PDZ binding motif (TAZ), play critical roles during angiogenesis. In this review, we summarize the mechanisms by which YAP/TAZ regulate endothelial cell shape, behavior, and function in angiogenesis. We further discuss how YAP/TAZ function as part of developmental and pathological angiogenesis. Finally, we review the role of YAP/TAZ in tumor vascular mimicry and propose directions for future work. View Full-Text
Keywords: Hippo pathway; cancer; angiogenesis; vascular mimicry; YAP; TAZ; MST1/2; LATS1/2 Hippo pathway; cancer; angiogenesis; vascular mimicry; YAP; TAZ; MST1/2; LATS1/2

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Azad, T.; Ghahremani, M.; Yang, X. The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry. Cells 2019, 8, 407.

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