Special Issue "New Advances in Cyclic AMP Signalling"
Deadline for manuscript submissions: closed (31 May 2020).
Interests: cell signalling; cyclic AMP; gene expression
Special Issues and Collections in MDPI journals
The cyclic nucleotide, cyclic 3’,5’-adenosine monophosphate (cyclic AMP), is the prototypical member of the family of second messengers, which mediates the intracellular actions of a wide range of cell surface receptors for hormones, neurotransmitters, growth factors, as well as sensory stimuli. Cyclic AMP is now recognised as a universal regulator of cellular function in a wide variety of organisms including protozoa, plants and animals. Cyclic AMP signalling is now known to occur in discrete sub-cellular compartments and is now widely viewed as the paradigm for “compartmentalised” cellular signalling in biological systems. Biological processes mediated by cyclic AMP include memory formation, metabolism, gene regulation, and immune function, and its deregulation is associated with many pathologies, including metabolic, cardiovascular, pulmonary and inflammatory disorders, as well as certain cancers.
Cyclic AMP is synthesised intracellularly following activation of GPCRs by physiological stimuli, thereby translating extracellular ligand binding into intracellular signals by virtue of conformational changes in the receptor that traverse the cell membrane. These structural effects result in the dissociation of Ga and Gβγ heterotrimeric G-protein subunits in the plasma membrane 1. It is the stimulatory, the Gsa subunit that is specifically involved in the synthesis of cyclic AMP since it activates adenylate cyclase (AC) at the plasma membrane, thereby catalysing the conversion of ATP into cyclic AMP and pyrophosphate. In contrast, inhibitory Gia subunits block AC activation, thereby limiting cyclic AMP production. Elevated intracellular cyclic AMP levels are able to activate a select range of signalling pathways through specific interactions with effector proteins that contain cyclic nucleotide binding domains (CNBs). These include protein kinase A (PKA), exchange protein activated by cyclic AMP (EPACs 1 and 2), cyclic AMP responsive ion channels (CICs) and Popeye domain-containing proteins (POPDCs). Activation of these proteins by cyclic AMP controls many aspects of cellular function, including proliferation, differentiation, secretion, cell spreading, inflammation, contractility and plasma membrane remodelling. As such, cyclic AMP signalling has become an attractive target for drug development for the treatment for a large variety of diseases.
This Special Issue of Cells is devoted to all aspects of cyclic AMP signalling in humans and other organisms. It will contain articles that collectively provide a balanced, state-of-the-art view of cyclic AMP signalling biology. We seek submissions of high-quality articles including but not limited to the control of cyclic AMP synthesis and degradation, the cell biology of cyclic AMP effectors, the compartmentalisation of cyclic AMP signalling components, drug development and physiological regulation in health and disease in humans and other model organisms.Prof. Stephen Yarwood
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cyclic AMP
- compartmentalised signalling
- drug development