Mechanisms of Cell Death in Neonatal Brain Injury

Dear Colleagues,

Neonatal brain injury remains a significant cause of long-term neurological and physical disability, placing significant emotional and socioeconomic burdens on families and society. Limited therapies exist to counteract such injuries, and although many are investigated in the laboratory, few make it to clinic. Development of a successful therapy is hindered by the complexity of molecular pathways initiated in the neonatal brain in response to stresses such as infection, toxicant exposure or nutrient/oxygen deprivation.

Our understanding of cell death mechanisms has undergone a revolution over the last decade, and we now need to evaluate how these more recently identified pathways (necroptosis, pyroptosis, ferroptosis, and autophagic cell death, among a myriad of others) impact the neonatal brain. It is also clear that cell death mechanism(s) are intertwined with factors incorporating the severity of insult, cell type, metabolic profile, sex, and developmental window.

Articles collected together in this Special Issue will focus on discerning the molecular mechanisms and regulators of cell death triggered in the immature brain in response to a variety of neonatal brain injury paradigms. Such data are vital if new avenues for therapeutic intervention are to be identified for the successful treatment of neonatal brain injury and associated neurodevelopmental disorders.

Dr. Claire Thornton
Guest Editor

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