Special Issue "Autophagy in Age-Related Human Diseases"
Deadline for manuscript submissions: 31 December 2018
Prof. Dr. Tassula Proikas-Cezanne
Increasingly, the process of autophagy (“self-eating”) is attracting tremendous research efforts. Exciting new data are shedding light on the molecular details of the process of autophagy and its pertubation in human diseases. Moreover, it is becoming evident that autophagy activity and capacity decrease during the aging process, giving rise to the onset of a great variety of age-related diseases. Strikingly, autophagy is also essential to the development of certain diseases (e.g. tumor progression). Hence, the modulation of autophagy is regarded as a new therapeutic opportunity for the future treatment of many pathological conditions. Further, targeting autophagy during the aging process may in fact prove to effectively prevent the onset of age-related human diseases. However, specific autophagy modulators have not yet been developed and tested.
This special issue aims to summarize the current knowledge on the role of autophagy in the process of aging and in age-related human diseases such as neurodegeneration and cancer.
We look forward to your contributions.Prof. Dr. Tassula Proikas-Cezanne
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Tentative title: Infections in aging: a link between autophagy and senesce
Author: Dr. Maria Isabel Colombo
Affiliation: Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
2. Tentative title: Autophagy in age-associated neurodegeneration
Author: Prof. Nektarios Tavernarakis
Affiliation: Foundation for Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, Heraklion, Greece
3. Tentative title: Autophagy in brain functions
Author: Dr. Patrice Codogno
Affiliation: CNRS Centre National de la Recherche Scientifique, Paris, France
4. Tentative title: Autophagy in metabolic age-related human diseases
Authors: James T. Murray and Cecile Vindis
Abstract: Autophagy is a highly conserved mechanism that mediates degradation of unhealthy organelles, protein aggregates, and invading pathogens, as well as recycling of cellular components that ultimately contributes to cellular renovation and homeostasis maintenance. In the last few years specific functions for autophagy have been identified in many tissues and organs. However dysregulation of autophagy has been identified as a feature of various pathologic states. Here, we review the current knowledge on the role of autophagy, from its regulation to its physiological influence, on metabolic age-related disorders. Finally, we will discuss the therapeutic potential of pharmacological and nutritional modulators of autophagy for treatment of metabolic diseases.
5. Tentative title: Novel modulators of proteostasis in C. elegans: RNAi screen of chromosome I in a heat stress paradigm
Authors: Andreas Kern, Natalie Spang, Heike Huesmann, Christian Behl
Affiliation: Johannes Gutenberg Universitat Mainz, Institute of Physiological Chemistry and Pathobiochemistry, Mainz, Germany