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Cells 2018, 7(10), 149; https://doi.org/10.3390/cells7100149

Autophagy in Metabolic Age-Related Human Diseases

INSERM, UMR-1048, Institute of Cardiovascular and Metabolic Diseases and University Paul Sabatier; F-31342 Toulouse, France
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Received: 22 August 2018 / Revised: 20 September 2018 / Accepted: 21 September 2018 / Published: 24 September 2018
(This article belongs to the Special Issue Autophagy in Age-Related Human Diseases)
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Abstract

Autophagy is a highly conserved homeostatic cellular mechanism that mediates the degradation of damaged organelles, protein aggregates, and invading pathogens through a lysosome-dependent pathway. Over the last few years, specific functions of autophagy have been discovered in many tissues and organs; however, abnormal upregulation or downregulation of autophagy has been depicted as an attribute of a variety of pathologic conditions. In this review, we will describe the current knowledge on the role of autophagy, from its regulation to its physiological influence, in metabolic age-related disorders. Finally, we propose to discuss the therapeutic potential of pharmacological and nutritional modulators of autophagy to treat metabolic diseases. View Full-Text
Keywords: autophagy; metabolism; diabetes; obesity; liver diseases; atherosclerosis; pharmacological modulators autophagy; metabolism; diabetes; obesity; liver diseases; atherosclerosis; pharmacological modulators
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Moulis, M.; Vindis, C. Autophagy in Metabolic Age-Related Human Diseases. Cells 2018, 7, 149.

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