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Cells 2018, 7(10), 162; https://doi.org/10.3390/cells7100162

Chronic Infections: A Possible Scenario for Autophagy and Senescence Cross-Talk

1
IHEM, Universidad Nacional de Cuyo, CONICET, Facultad de Ciencias Médicas, Mendoza 5500, Argentina
2
Facultad de Odontología, Universidad Nacional de Cuyo, Mendoza 5500, Argentina
3
Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, Mendoza 5500, Argentina
4
Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza 5500, Argentina
*
Author to whom correspondence should be addressed.
Received: 15 August 2018 / Revised: 4 October 2018 / Accepted: 7 October 2018 / Published: 10 October 2018
(This article belongs to the Special Issue Autophagy in Age-Related Human Diseases)
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Abstract

Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process called immunosenescence, giving rise to a chronic inflammatory status of the organism, with a decreased ability to counteract antigens. The obvious result of this process is a reduced defence capacity. Currently, there is evidence that some pathogens are able to accelerate the immunosenescence process for their own benefit. Although to date numerous reports show the autophagy–senescence relationship, or the connection between pathogens with autophagy or senescence, the link between the three actors remains unexplored. In this review, we have summarized current knowledge about important issues related to aging, senescence, and autophagy. View Full-Text
Keywords: aging; senescence; autophagy; immune system; immunosenescence; pathogens; chronic infections aging; senescence; autophagy; immune system; immunosenescence; pathogens; chronic infections
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Aguilera, M.O.; Delgui, L.R.; Romano, P.S.; Colombo, M.I. Chronic Infections: A Possible Scenario for Autophagy and Senescence Cross-Talk. Cells 2018, 7, 162.

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