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Cells 2018, 7(5), 37; https://doi.org/10.3390/cells7050037

Autophagy in Age-Associated Neurodegeneration

1
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Crete, Greece
2
Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion 70013, Crete, Greece
These authors have contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 2 April 2018 / Revised: 23 April 2018 / Accepted: 3 May 2018 / Published: 5 May 2018
(This article belongs to the Special Issue Autophagy in Age-Related Human Diseases)
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Abstract

The elimination of abnormal and dysfunctional cellular constituents is an essential prerequisite for nerve cells to maintain their homeostasis and proper function. This is mainly achieved through autophagy, a process that eliminates abnormal and dysfunctional cellular components, including misfolded proteins and damaged organelles. Several studies suggest that age-related decline of autophagy impedes neuronal homeostasis and, subsequently, leads to the progression of neurodegenerative disorders due to the accumulation of toxic protein aggregates in neurons. Here, we discuss the involvement of autophagy perturbation in neurodegeneration and present evidence indicating that upregulation of autophagy holds potential for the development of therapeutic interventions towards confronting neurodegenerative diseases in humans. View Full-Text
Keywords: ageing; Alzheimer’s disease; amyotrophic lateral sclerosis; autophagy; Huntington’s disease; mitophagy; neurodegeneration; Parkinson’s sisease; protein aggregation; treatment ageing; Alzheimer’s disease; amyotrophic lateral sclerosis; autophagy; Huntington’s disease; mitophagy; neurodegeneration; Parkinson’s sisease; protein aggregation; treatment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Metaxakis, A.; Ploumi, C.; Tavernarakis, N. Autophagy in Age-Associated Neurodegeneration. Cells 2018, 7, 37.

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