Arteriogenesis and Therapeutic Neovascularization

Dear Colleagues,

Arteriogenesis, also frequently called collateral formation or even therapeutic angiogenesis, comprises those processes that lead to the formation and growth of collateral blood vessels that can act as natural bypasses to restore blood flow to distal tissues in occluded arteries. Both in coronary occlusive artery diseases as well as in peripheral occlusive arterial disease, arteriogenesis may play an important role in the restoration of blood flow. Despite the big clinical potential and the many promising clinical trials on arteriogenesis and therapeutic angiogenesis, the exact molecular mechanisms involved in the multifactorial processes of arteriogenesis are still not completely understood. In this inflammatory-driven vascular remodeling process, many cell types, both vascular cells and immune cells, many cytokines and growth factors, as well as various noncoding RNAs or progenitor cells may be involved. Consequently, many questions regarding the exact molecular mechanisms involved in the regulation of the arteriogenic response still need to be answered, and these answers will contribute to defining new therapeutic options.

This Special Issue of Cells is devoted to all aspects of arteriogenesis and collateral formation. It will contain articles that collectively provide a balanced, state-of-the-art view on various aspects of arteriogenesis and the underlying regulation of vascular remodeling. We seek submissions of high-quality articles on all aspects of arteriogenesis, including but not limited to regulatory mechanisms, the cell types involved, state-of-the-art models, latest (pre)clinical developments, and therapeutic options.

Prof. Elisabeth Deindl
Prof. Paul H. Quax
Prof. Johannes Waltenberger
Prof. Thomas Schmitz-Rixen
Guest Editors

Manuscript Submission Information

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