Special Issue "Nuclear Architecture, Lipids, and Phase Separation"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".

Deadline for manuscript submissions: 15 January 2020.

Special Issue Editors

Prof. Dr. Pavel Hozák
E-Mail Website
Guest Editor
Institute of Molecular Genetics AS CR, Laboratory of Biology of the Cell Nucleus and Microscopy Centre, Videnska 1083, 142 20 Prague, Czech Republic
Interests: cell nucleus; nucleolus; regulation of gene expression; epigenetics; nucleoskeleton; nuclear myosins; actin-related proteins and phospholipids; lamins; laminopathies; phase separation; microscopy
Prof. Dr. Ohad Medalia
E-Mail Website
Guest Editor
1 Department of Biochemistry, University of Zurich, Zurich, Switzerland
2 Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University, Beer-Sheva, Israel
Interests: nuclear envelope, lamins, cell adhesion, cryo-electron tomography
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Special Issue Information

Dear Colleagues,

We are delighted to invite you to contribute to a special Cells issue, the basis of which will be selected from the presentations at the workshop “Nuclear Architecture, Lipids, and Phase Separation”, taking place in Prague, 24–25 October, 2019 (https://eurocellnet.eu/workshop2019/).
The molecular organization within the cell nucleus determines gene expression, and recent observations revolutionize our understanding of nuclear architecture. In particular, the molecular functions of intra-nuclear lipids involved in RNA polymerase II transcription and modulation of RNA polymerase I activity at multiple levels suggest additional functions of lipids. The aim of the workshop and this Special Issue is to provide insight into state of the art methods and data available about the precise localization and metabolism of nuclear lipid-containing structures, as well as to discuss the diverse functional implications of these nuclear molecular assemblies in gene expression. Special attention will be given to multidisciplinary approaches, including light and electron (cryo)-microscopy, lipid chemistry, and biophysics, addressing the mechanotransduction and phase separation events in the nucleus with the potential to form novel views on functions of macromolecular assemblies in the nucleus and nucleoplasmic lipids.

We are looking forward to your contributions to this Special Issue.

Prof. Dr. Pavel Hozák
Prof. Dr. Ohad Medalia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nuclear architecture and compartmentalization;
  • Nucleoskeleton;
  • Epigenetics;
  • Phase separation;
  • Nuclear lipids;
  • Regulation of gene expression;
  • Nuclear pathology;
  • Advanced microscopy.

Published Papers (1 paper)

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Review

Open AccessFeature PaperReview
Nuclear Phosphoinositides—Versatile Regulators of Genome Functions
Cells 2019, 8(7), 649; https://doi.org/10.3390/cells8070649 - 28 Jun 2019
Cited by 1
Abstract
The many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in [...] Read more.
The many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2’s role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets—recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide–protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies. Full article
(This article belongs to the Special Issue Nuclear Architecture, Lipids, and Phase Separation)
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