Telomeres at the Crossroad of DNA Repair Pathways
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 7623
Special Issue Editor
Special Issue Information
Dear Colleagues,
The fields of telomere biology and DNA repair have experienced convergence and cross-fertilization throughout years. Seminal contributions from both fields have been awarded Nobel prizes in Physiology-Medicine and Chemistry, in 2009 and 2015, respectively. In particular, the understanding of telomere biology provides but at the same time requires insights into the nature and regulation of DNA repair pathways. Telomeres function at chromosome ends to block unwarranted activation of DNA repair machineries. Therefore, knowledge of DNA damage response (DDR) pathways may unveil the regulatory nodes that lie at the interface between telomere biology and repair processes. DDR factors serve protective roles and help preserve telomere integrity. Conversely, dysfunctional telomeres have provided a platform for a better understanding of the nature of cellular DDR, unveiling specific aspects that are otherwise not readily evident from the analysis of genomic DNA damage. This Special Issue is therefore meant to focus on the convergence of DNA repair mechanisms and telomere biology and aims to foster a stimulating interdisciplinary synergy between these two fields.
Dr. Antonio Porro
Guest Editor
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Keywords
- telomeres
- DNA repair
- DNA damage
- response
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