Special Issue "TRPC Channels"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: molecular physiology of TRPC channels; cation channels; Ca2+ influx; electrophysiology
Special Issues and Collections in MDPI journals
Transient receptor potential canonical (TRPC) channels belong to the superfamily of TRP cation channels. There are seven members in the TRPC subfamily, with TRPC2 being a pseudogene in humans. TRPCs are Ca2+ permeable, non-selective cation channels that are capable of mediating a significant Ca2+ influx into cells. A growing body of evidence indicates that TRPC channels are involved in regulating neurite outgrowth, axon guidance, neurodegeneration, endothelium-mediated vasodilation, smooth muscle cell contraction, etc. TRPC genes are associated with human diseases such as focal segmental glomerulosclerosis, hypertrophic pyloric stenosis, and spinocerebellar ataxia 41. The development of knockout mouse models and the discovery of several selective small molecule modulators of TRPC channels have been crucial for the beginning of our understanding of TRPC function in health and disease, which is an ongoing endeavour. The most recent scientific breakthrough in the TRPC field has been the solving of the cryo-electron microscopy structures of several TRPC proteins (TRPC3, TRPC4, TRPC5, and TRPC6). These advances have opened new horizons for deciphering the precise molecular mechanisms underlying TRPC functional activity. This Special Issue will provide an open access platform for reviews and original research papers describing new findings in the TRPC field, covering any topics related to the channels’ biophysics, structure, and/or physiological/pathophysiological roles.
Dr. Alexander G. Obukhov
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- TRPC channels
- Cation channels
- Molecular physiology
- TRPC channel structure
- TRPC channel regulation
- Transcriptional gene regulation