Molecular Mechanism of Stress, Stress Response, and Adaptation

Dear Colleagues, 

Stress is an unavoidable event in a living body. Moderate stress is necessary in many physiological events such as development, growth, and aging (differentiation, proliferation, and cell death at cellular level, respectively). However, excessive stress may cause various kinds of pathological conditions, including inflammation, degeneration, and cancer. Cells or organs try to survive with clever and delicate mechanisms, sometimes by responding to and sometimes by adapting to excessive stresses. By contrast, cells or organs will respectively respond to stress by dying or falling into dysfunction. Very smartly, cells or organs suffering from properly managed, nonlethal stress will learn how to withstand stress and prepare for lethal stress coming in the near future.

This Special Issue will focus especially on stress “response” and “adaptation” in excessively stressed cells/organs, including basic response (differentiation, proliferation, growth, programmed death, etc.) at the cellular level and adaptive response (preconditioning, regeneration, degeneration, etc.) at the organ level. Studies on the pathogenesis and prevention of various stress-associated diseases at the cellular/molecular levels are also welcome. 

Prof. Dr. Michitaka Ozaki
Guest Editor

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