Special Issue "Molecular Mechanism of Stress, Stress Response, and Adaptation"

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 20 October 2022.

Special Issue Editor

Prof. Dr. Michitaka Ozaki
E-Mail Website
Guest Editor
Department of Biological Response and Regulation, Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan
Interests: oxidative stress; ischemia/reperfusion(hypoxia/reoxygenation)-induced injury; programmed cell death; redox signaling; optogenetics

Special Issue Information

Dear Colleagues, 

Stress is an unavoidable event in a living body. Moderate stress is necessary in many physiological events such as development, growth, and aging (differentiation, proliferation, and cell death at cellular level, respectively). However, excessive stress may cause various kinds of pathological conditions, including inflammation, degeneration, and cancer. Cells or organs try to survive with clever and delicate mechanisms, sometimes by responding to and sometimes by adapting to excessive stresses. By contrast, cells or organs will respectively respond to stress by dying or falling into dysfunction. Very smartly, cells or organs suffering from properly managed, nonlethal stress will learn how to withstand stress and prepare for lethal stress coming in the near future.

This Special Issue will focus especially on stress “response” and “adaptation” in excessively stressed cells/organs, including basic response (differentiation, proliferation, growth, programmed death, etc.) at the cellular level and adaptive response (preconditioning, regeneration, degeneration, etc.) at the organ level. Studies on the pathogenesis and prevention of various stress-associated diseases at the cellular/molecular levels are also welcome. 

Prof. Dr. Michitaka Ozaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cell proliferation
  • cell growth, programmed cell death
  • preconditioning
  • sterile inflammation
  • oxidative stress
  • hypoxia (ischemia)
  • reoxygenation (reperfusion), metabolic stress
  • heat stress
  • ER stress
  • osmotic stress
  • mechanical stress

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Iron and oxidative stress: the mastermind behind human diseases
Authors: Treruyuki Kawabata
Affiliation: Department of Applied Physics, Graduate School of Science, Okayama University of Science, 1-1 Ridai-cho, Kitaku, Okayama 700-0005 Japan
Abstract: /

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