Serotonin in Development and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (4 May 2022) | Viewed by 3649
Special Issue Editor
Special Issue Information
Dear Colleagues,
Serotonin (5-hydroxytryptamine or 5-HT) is a monoamine synthesized from the essential amino acid tryptophan. Although 5-HT was first identified as a substance with contracting properties found in gut cells, it was mostly studied as a neurotransmitter in the central nervous system. However, from the time when tryptophan hydroxylase—the rate limiting enzyme for its synthesis—was shown to exist in two isoforms, the study of both peripheral and central 5-HT revealed the critical roles played by the amine during development as well as in adult life.
Defects in 5-HT signaling have been linked to a variety of psychiatric syndromes as well as to obesity/diabetes and diseases of the cardiovascular system such as hypertension. Several studies have also revealed the role played by 5-HT in the pathophysiology of gastrointestinal tract disorders acting both as an enteric neurotransmitter and a mucosal signaling molecule.
The new era of 5-HT research includes its role as a regulator for the activities of hematopoietic stem cells, and in inflammatory and immunomodulatory diseases, its possible involvement as a growth factor for tumor cells, in addition to understanding the link between 5-HT, gut microbiota, and the brain.
Prof. Dr. Francine Côté
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- central and peripheral serotonin
- serotonergic network
- tryptophan hydroxylase
- neurotransmitter
- hormone
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
