Protein Mono-ADP-Ribosylation in the Control of Cell Functions
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 44484
Special Issue Editors
Interests: ADP-ribosylating toxins; enzymatic mechanisms; enzyme inhibitors; PARP biochemistry; X-ray crystallography
Interests: PARPs; mono-ADP-ribosylation; Golgi complex; intracellular transport; cell-cycle; apoptosis; stress response; post-translational modifications; cancer; signaling
Special Issue Information
Dear Colleagues,
Mono-ADP-ribosylation of proteins was discovered over 50 years ago, when it became clear that pathogenic bacteria express ADP-ribosylating toxins that inactivate host cell proteins. Later, it was found that higher eukaryotes possess homologs of one major clade of toxins, the Clostridium toxin-like ARTC enzymes, that have extracellular activities. Homologs of the second major clade of toxins, the diphtheria toxin-like ARTD enzymes—better known as PARPs (or poly-ADP-ribose- polymerases)—are instead represented in the cytosol and nuclei of eukaryotic cells, and are responsible for both poly- and mono-ADP-ribosylation of targets.
The study of mono-ADP-ribosylation, in particular, has been difficult owing to a lack of research tools as well as chemistry that is hard to detect by mass spectrometry and a transient nature that obstructs detection in cells and tissues. The new millennium and especially the past few years have brought a range of developments and discoveries that collectively represent a major advance for this research field. The definition of novel pathways driven by MARylation—from the RNA regulation to the control intracellular transport—along with the identification of specific inhibitors, will likely have an important impact on cell biology research, with potential applications for the treatment of diseases.
This Special Issue will give a timely view of the field of mono-ADP-ribosylation. Contributions by expert laboratories will present methods, tools, and functional advances. We hope that this collection of articles will be a useful summary for the mono-ADP-ribosylation experts as well as a helpful introduction for those colleagues who stumble upon the modification when studying other aspects of physiology and medicine.
Prof. Herwig Schüler
Dr. Giovanna Grimaldi
Guest Editors
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Keywords
- mono-ADP-ribosylation
- PARPs
- ADP-ribosylating toxins
- exo-mARTs
- Intracellular signaling
- oxidative stress
- PARP inhibitors
- mass-spectrometry
- post-translational modifications
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