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Special Issue "Nuclear Organisation"
Deadline for manuscript submissions: closed (15 September 2019).
Interests: nuclear envelope; nuclear pore complex; laminopathies; ageing; nuclear organisation; chromatin structure and function; gene regulation; chromosome segregation; nucleocytoplasmic transport; live microscopy
Special Issues and Collections in MDPI journals
The nucleus is a fascinating organelle of eukaryotic cells. It contains and organises the chromosomes, which implies that many biological processes depend on nuclear organisation, as well as regulated communication between the nucleus and its surrounding organelles and cytoplasm. The aim of this Special Issue of Cells is to provide a comprehensive overview of our current knowledge about the nucleus, spanning from the structure and function of the nuclear envelope to the three-dimensional organisation of chromosomes in territories and domains. Both fundamental aspects of cell biology and mechanisms to ensure and utilise cell type-specific nuclear organisation will be addressed by specialists that exploit a wide variety of genetical, biochemical, and genomics methods across different organisms.
Nuclear organisation is also highly relevant from a biomedical viewpoint. Since the discovery that mutations in nuclear envelope proteins cause a pleiotropy of severe human diseases, including muscular dystrophies, bone disorders, neuropathies, and even premature ageing, many efforts have been devoted to understanding the protective, scaffolding, and regulatory roles of the nuclear envelope. Modern advances in genomics have revealed that perturbations in the discrete folding of chromatin in topologically associating domains can also have profound effects during development. Most recently, multidisciplinary approaches have begun to unravel the principles underlying the segregation of heterochromatin from euchromatin—a separation that was already appreciated in early microscopy studies but is now better understood by employing epigenetics and biophysical tools. By integrating up-to-date insight from these different areas, we are in an unprecedented position to recognise the dynamics and implications of the incredible complexity found within our nuclei.
Dr. Peter Askjaer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Nuclear Envelope
- Chromatin Organisation
- Topologically Associating Domain
- Gene Expression
- Phase Separation