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Cells 2019, 8(2), 124;

Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling

Department of Medical Technology, Ehime Prefectural University of Health Sciences, 543 Takooda, Tobecho, Ehime 791-2102, Japan
Received: 23 December 2018 / Revised: 1 February 2019 / Accepted: 1 February 2019 / Published: 4 February 2019
(This article belongs to the Special Issue Nuclear Organisation)
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The primary functions of the nuclear envelope are to isolate the nucleoplasm and its contents from the cytoplasm as well as maintain the spatial and structural integrity of the nucleus. The nuclear envelope also plays a role in the transfer of various molecules and signals to and from the nucleus. To reach the nucleus, an extracellular signal must be transmitted across three biological membranes: the plasma membrane, as well as the inner and outer nuclear membranes. While signal transduction across the plasma membrane is well characterized, signal transduction across the nuclear envelope, which is essential for cellular functions such as transcriptional regulation and cell cycle progression, remains poorly understood. As a physical entity, the nuclear envelope, which contains more than 100 proteins, functions as a binding scaffold for both the cytoskeleton and the nucleoskeleton, and acts in mechanotransduction by relaying extracellular signals to the nucleus. Recent results show that the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, which is a conserved molecular bridge that spans the nuclear envelope and connects the nucleoskeleton and cytoskeleton, is also capable of transmitting information bidirectionally between the nucleus and the cytoplasm. This short review discusses bidirectional signal transduction across the nuclear envelope, with a particular focus on mechanotransduction. View Full-Text
Keywords: LINC complex; nuclear envelope; mechanotransduction; SUN protein; KASH protein LINC complex; nuclear envelope; mechanotransduction; SUN protein; KASH protein

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Hieda, M. Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling. Cells 2019, 8, 124.

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