NOX Enzymes from Host Defense to Cell Signaling and Metabolic Disease

Dear Colleagues,

NADPH oxidase enzymes (NOX-es) are a family of reactive oxygen species (ROS)-producing molecules who gained significant interest in studies concerning a wide variety of physiopathological processes. Indeed, different NOX-es are present in all cells types, and current knowledge indicates that their functions are unique to each isoform defined by cellular types and intracellular localization, and respond to diverse activation mechanisms. Due these features, NOX enzymes produce ROS in a timely and spatially regulated manner. This constrained ROS production predisposes NOX-es as critical regulatory components of physiological receptor signaling, cell division and survival, as well as metabolic processes. On the contrary, deregulation of NOX function resulting in unrestricted ROS production is recognized as one of the underlying constituents in various pathologies. Due to this diversity, NOX-es are investigated as potential pharmacological targets in miscellaneous pathological conditions. The understanding of proper regulation of cellular redox homeostasis and the role of NOX-es in this process is indispensable for identifying novel avenues to combat ROS-related pathologies. This Special Issue of Cells should improve our understanding of NOX function and regulation by including researchers working in the areas of inflammation, cell signaling and metabolism, cancer and fibrosis development. Studies conducted in cell-free systems, cellular or rodent models exploring both the physiological and pathological functions of NOX enzymes are encouraged. Investigations of NOX enzymes using diverse methods and research systems are urgently needed to improve our understanding of cellular redox-related pathophysiological processes.

Dr. Ildiko Szanto
Guest Editor

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• NOX enzymes
• inflammatory cells
• cell cycle regulation
• apoptosis
• metabolism
• fibrosis
• diabetes