Molecular Mechanisms and Potential Therapeutics for Organ/Tissue Repair and Regeneration

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 2993

Special Issue Editors

Burnett School of Biomedical Sciences, UCF College of Medicine, 6900 Lake Nona Blvd, Orlando, FL, USA
Interests: nanoparticles-based radioprotective therapy; bone regeneration; bioactive materials; exosomes; hard tissue regeneration

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Guest Editor
School of Dentistry, The University of Queensland, Herston, Australia
Interests: Translational ImmunoEngineering for Regenerative Dentistry; bone repair and regeneration; stem cell therapy; biomaterial application

Special Issue Information

Dear Colleagues,

Tissue or organs damage due to trauma, diseases, or congenital defects is very common in humans.

Due to the low regenerative ability of human organs, tissue and organ regeneration or shortages have been identified as a major public health challenge globally. Currently, organ transplantation is the standard treatment for end-stage organ failure.

Therefore, identification of the key factors, pathways, or cells involved in the organ’s regenerative stages would be tremendously helpful to identify novel therapeutics. The goal of organ regeneration is to use bioactive molecules, exogenous therapeutic cells, engineered functional constructs or artificial organs, etc., to repair or replace damaged tissues or whole organs, so the patients can return to a normal life.

The aim of this Special Issue is to assemble original research papers and reviews illustrating the latest molecular and cellular mechanisms involved in small or large organ regeneration, including thymus, thyroid gland, lung, liver, kidney, heart, intestine, blood vessels, central nervous system, skin, ocular tissue, calcified tissue, cartilage, etc. The current advancement in regenerative medicine to replace, accelerate, or support tissue or organ regeneration will also be highlighted.

Dr. Fei Wei
Dr. Yinghong Zhou
Guest Editors

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Keywords

  • tissue regeneration
  • organ regeneration
  • molecular and cellular mechanism
  • regenerative medicine
  • regenerative cells

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Published Papers (1 paper)

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Review

22 pages, 1643 KiB  
Review
Decellularization of Dense Regular Connective Tissue—Cellular and Molecular Modification with Applications in Regenerative Medicine
by Krzysztof Data, Magdalena Kulus, Hanna Ziemak, Mikołaj Chwarzyński, Hanna Piotrowska-Kempisty, Dorota Bukowska, Paweł Antosik, Paul Mozdziak and Bartosz Kempisty
Cells 2023, 12(18), 2293; https://doi.org/10.3390/cells12182293 - 16 Sep 2023
Viewed by 2693
Abstract
Healing of dense regular connective tissue, due to a high fiber-to-cell ratio and low metabolic activity and regeneration potential, frequently requires surgical implantation or reconstruction with high risk of reinjury. An alternative to synthetic implants is using bioscaffolds obtained through decellularization, a process [...] Read more.
Healing of dense regular connective tissue, due to a high fiber-to-cell ratio and low metabolic activity and regeneration potential, frequently requires surgical implantation or reconstruction with high risk of reinjury. An alternative to synthetic implants is using bioscaffolds obtained through decellularization, a process where the aim is to extract cells from the tissue while preserving the tissue-specific native molecular structure of the ECM. Proteins, lipids, nucleic acids and other various extracellular molecules are largely involved in differentiation, proliferation, vascularization and collagen fibers deposit, making them the crucial processes in tissue regeneration. Because of the multiple possible forms of cell extraction, there is no standardized protocol in dense regular connective tissue (DRCT). Many modifications of the structure, shape and composition of the bioscaffold have also been described to improve the therapeutic result following the implantation of decellularized connective tissue. The available data provide a valuable source of crucial information. However, the wide spectrum of decellularization makes it important to understand the key aspects of bioscaffolds relative to their potential use in tissue regeneration. Full article
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