Special Issue "Structure and Function of Healthy and Diseased Myelin"
Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 22419
Myelin is a specialized biomembrane in the nervous system of vertebrates, although myelin-like structures can be detected in lower organisms. The unique, restricted biochemical composition of the myelin membrane allows it to form multilayered structures and to carry out specific functions, but also makes it prone to disease-inducing mutations that affect its molecular components. While the function of myelin was for a long time thought to simply enable saltatory nerve impulse conduction, intense research during recent years has drawn a much more complex picture of myelin biochemistry. Metabolic, trophic, and signalling functions are now recognized components of the functional repertoire of myelin sheaths. A coordinated interplay between the myelinating cell cytoskeleton, proteins residing on the myelin membrane, and extracellular ligands is crucial for the correct formation and stability of myelin. Meanwhile, the molecular structure of the myelin proteolipid membrane at high resolution remains to be visualized. Studies in recent years have provided a wealth of data on the structure and properties of myelin molecules, including integral membrane proteins. We can expect a more complete structural description of the native myelin membrane at the molecular level in the future.
This Special Issue of Cells will welcome papers on all aspects of myelin research, from theoretical and basic science to applications and myelin disease. It aims to provide an update on different fields of myelin-related research, to enable an overall understanding of myelin structure and function at different levels of complexity.
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- structural biology