Molecular Chaperone: Cancer and Cell Death 2021
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3722
Special Issue Editor
Interests: molecular chaperones; protein–protein interactions; molecular targets in anticancer therapy; propagation of neurodegenerative pathologies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The analysis of systems maintaining cell proteostasis and based on molecular chaperones shows that these mechanisms are closely associated with the molecular systems controlling cell survival, growth, and proliferation. Moreover, chaperones are essential to the immunological response to a variety of pathogenic as well as therapeutic factors. It is also important to note that elevating the chaperone content in cells increases their protection against harmful agents. Cancer cells of many types overexpress chaperones to fight against well-known stressors, such as oxidative stress and hypoxia, as well as against antitumor medicines, particularly drugs inducing apoptosis. Generally, chaperones are activated by transcriptional signals controlling the behavior of a cell in changing surroundings, while, functionally, the chaperones are involved in the most important processes, defining a compromise between cell death, life, and growth and being implicated in apoptosis, autophagy, and protein quality control. Therefore, targeting molecular chaperones may cause fluctuations in different signaling systems, and such inhibition has been shown to result in tumor delay or death. Strikingly, some chaperones occurring exogenously play a pivotal role in the induction of the immunological response to tumors, and this effect is employed in the protocols of the immunotherapy of hard tumors.
The role of molecular chaperones in human pathologies is contradictory, and in cancer therapy, we should employ instruments suppressing chaperones; while fighting against pathogenic factors affecting normal cells, the activity of the heat shock proteins must be increased.
The goal of this Special Issue is to broadly present the current knowledge on the role of chaperones in the process of cancer progression and normal cell death/survival.
We look forward to your contributions.
Prof. Boris Margulis
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chaperones
- cancer
- heat shock
- proteins immunotherapy
