Metabolic Mechanisms of Aging and Aging-Related Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (25 July 2022) | Viewed by 12367
Special Issue Editor
Special Issue Information
Dear Colleagues,
Aging is biologically defined as a decline in locomotory and physiological performances along with increased morbidity, which spans from the completion of post-natal growth until the death of animal organisms. In human societies, the socio-economic costs resulting from this process prompt us to need to understand its underlying mechanisms and to find out some interventional cues to reduce or delay age-related diseases, i.e., to increase healthspan (healthy lifespan). Basic research has recently outlined nine universal hallmarks of aging, several of which directly concern metabolism: mitochondrial dysfunction, loss of proteostasis, dysregulated nutrient sensing, and altered intercellular communication. In addition, two sets of behaviors were extensively demonstrated to improve healthspan: alimentary restriction without malnutrition and daily physical activity, which directly impacts metabolic processes. Therefore, the aim of this Special Issue is to review the metabolic mechanisms underlying aging, age-related diseases, and the two major preventive strategies for healthy aging.
Prof. Dr. Emmanuel Moyse
Guest Editor
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Keywords
- mitochondria
- oxidative stress
- energetic metabolism
- catabolism
- anabolism
- protein turn-over
- sarcopenia
- body weight
- atherosclerosis
- diabetes
- hypertension
- insulin
- leptin
- hormone resistance
- extracellular signal receptors
- risk factors
- caloric restriction
- denutrition
- cachexia
- fat mass
- lean mass
- centenarians
- longevity genes
- tumor suppressor
- cellular senescence
- tissue self-renewal
- stem cells
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