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Cells
Special Issues
Development and Differentiation of Mammalian Germ Cells
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Development and Differentiation of Mammalian Germ Cells

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 2671

Special Issue Editors

Dr. Patricio J. Morales

E-Mail Website
Guest Editor
Biomedical Department, Faculty of Health Sciences, University of Antofagasta, Antofagasta, Chile
Interests: sperm physiology; acrosome reaction; capacitation; infertility
Dr. Milene Kong

E-Mail Website
Guest Editor
Laboratory of Biology of Reproduction, Department of Biomedicine, Faculty of Health Sciences, University of Antofagasta, Antofagasta, Chile
Interests: signaling pathway; acrosome reaction; capacitation
Dr. Héctor Zapata-Carmona

E-Mail Website
Guest Editor
Laboratory of Biology of Reproduction, Department of Biomedicine, Faculty of Health Sciences, University of Antofagasta, Antofagasta, Chile
Interests: reproductive biology; signaling pathway; spermatogenesis; male infertility; in vitro fertilization

Special Issue Information

Dear Colleagues,

This Special Issue, titled “Development and Differentiation of Mammalian Germ Cells”, aims to create a collection of manuscripts providing new evidence available on the cellular and molecular mechanisms of mammalian germ cell differentiation.

Germ cells are essential for reproduction and the continuation of species. The germ cell development and differentiation are highly dynamic processes that span the animal’s life cycle. The germline life cycle begins in the gonad development during embryogenesis and continues during gametogenesis, leading to fully differentiated and mature gametes that fuse during fertilization.

There are many open questions regarding the development and differentiation of germ cells. Moreover, defects in these processes can lead to infertility. To provide an integrated view of these processes authors are invited to submit manuscripts that will advance the knowledge in the field of reproduction. This Special Issue will publish full research articles and comprehensive reviews. Potential topics include, but are not limited to, the following research areas:

  • Primordial germ cell migration;
  • Gonad development;
  • Oogenesis;
  • Spermatogenesis;
  • Fertilization.

Dr. Patricio J. Morales
Dr. Milene Kong
Dr. Héctor Zapata-Carmona
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • germ cells
  • mammalian gametogenesis
  • fertilization
  • infertility
  • mammalian gametes

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  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Review

15 pages, 1916 KiB  
Review
Consequences of Exposure to Hypobaric Hypoxia Associated with High Altitude on Spermatogenesis and Seminal Parameters: A Literature Review
by Carlos Cornejo-Guerra, Camila Salazar-Ardiles, Patricio Morales and David C. Andrade
Cells 2024, 13(7), 592; https://doi.org/10.3390/cells13070592 - 29 Mar 2024
Cited by 1 | Viewed by 2159
Abstract
Preclinical research has provided compelling evidence indicating that exposure to hypobaric hypoxia (HH) results in a deterioration of spermatogenesis. This adverse effect extends to the underlying molecular mechanisms, progressively leading to impairments in the seminiferous epithelium and germ cells and alterations in semen [...] Read more.
Preclinical research has provided compelling evidence indicating that exposure to hypobaric hypoxia (HH) results in a deterioration of spermatogenesis. This adverse effect extends to the underlying molecular mechanisms, progressively leading to impairments in the seminiferous epithelium and germ cells and alterations in semen parameters. Indeed, several studies have demonstrated that animals exposed to HH, whether in natural high-altitude environments or under simulated hypoxic conditions, exhibit damage to the self-renewal and differentiation of spermatogenesis, an increase in germline cell apoptosis, and structural alterations in the seminiferous tubules. One of the primary mechanisms associated with the inhibition of differentiation and an increase in apoptosis among germ cells is an elevated level of oxidative stress, which has been closely associated with HH exposure. Human studies have shown that individuals exposed to HH, such as mountaineers and alpinists, exhibit decreased sperm count, reduced motility, diminished viability, and increased sperm with abnormal morphology in their semen. This evidence strongly suggests that exposure to HH may be considered a significant risk factor that could elevate the prevalence of male infertility. This literature review aims to provide a comprehensive description and propose potential mechanisms that could elucidate the infertility processes induced by HH. By doing so, it contributes to expanding our understanding of the challenges posed by extreme environments on human physiology, opening new avenues for research in this field. Full article
(This article belongs to the Special Issue Development and Differentiation of Mammalian Germ Cells)
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