Novel Insight into Endothelial Function and Atherosclerosis

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 2390

Special Issue Editors


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Guest Editor
Department of Experimental and Clinical Medicine, Magna Græcia University, Catanzaro, Italy
Interests: atherosclerosis; endothelial function; blood viscosity; carotid artery; diabetes
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Guest Editor
Dana Faber Cancer Institute – Harvard Medical School, Boston, MA 02215, USA
Interests: biomarker; diabetes; metabolism; immunology; cancer

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Guest Editor
Technology and Medical Sciences, University Magna Græcia, 88100 Catanzaro, Italy
Interests: non-invasive diagnosis of preclinical atherosclerosis; hemorheology (blood and plasma viscosity, and hematocrit); haemodynamic (shear stress, circumferential wall tension, tensile stress); endothelial function; continuous glucose monitoring; telemedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Atherosclerotic disease is one of the most common and serious problems of modern medicine. It is known as a chronic inflammatory disease involving arteries; however, it is much more than that and involves from metabolism to immunology, and from hemorheology to hemodynamics, each of these aspects contributes to its development. Endothelial function plays a crucial role in the development and progression of atherosclerosis. The endothelium, the inner layer of the blood vessel wall, regulates vascular homeostasis, primarily through the production of vasodilatory and anti-inflammatory agents, among them being nitric oxide (NO). If the role of the endothelium in the process of atherosclerosis is of extreme importance in this research area, it is yet poorly considered as a possible target. A deeper understanding of the mechanisms behind endothelial dysfunction, from different points of view, could certainly help to cure atherosclerosis.

This Special Issue aims to provide a collection of the current knowledge and novel insights into endothelial function and atherosclerosis.

We are pleased to invite you as a recognized expert in the field to contribute original articles, communications, and reviews covering the entire field of endothelial function and atherosclerosis, including (but not limited to) the following:

  • Immunometabolism and atherosclerosis;
  • The novel biomarkers of endothelial dysfunction and atherosclerosis;
  • The role of hemorheology and hemodynamics in atherosclerosis;
  • The endothelial cell dysfunction and pathobiology of atherosclerosis;
  • Advances in the assessment of endothelial function;
  • Vascular biology and microcirculation.

We look forward to receiving your contributions.

Dr. Antonio Cutruzzolà
Dr. Alessandro Salatino
Prof. Dr. Concetta Irace
Guest Editors

Manuscript Submission Information

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Keywords

  • atherosclerosis 
  • endothelial function 
  • nitric oxide 
  • flow-mediated dilation 
  • biomarkers 
  • imaging 
  • arterial wall 
  • endothelium 
  • inflammation

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Published Papers (1 paper)

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Review

17 pages, 702 KiB  
Review
The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction?
by Marco Paolo Donadini, Francesca Calcaterra, Erica Romualdi, Roberta Ciceri, Assunta Cancellara, Corrado Lodigiani, Monica Bacci, Silvia Della Bella, Walter Ageno and Domenico Mavilio
Cells 2025, 14(2), 144; https://doi.org/10.3390/cells14020144 - 20 Jan 2025
Cited by 3 | Viewed by 1804
Abstract
Venous thromboembolism (VTE) and arterial thrombosis (AT) are distinct yet closely related pathological processes. While traditionally considered separate entities, accumulating evidence suggests that they share common risk factors, such as inflammation and endothelial dysfunction (ED). This review explores the parallels and differences between [...] Read more.
Venous thromboembolism (VTE) and arterial thrombosis (AT) are distinct yet closely related pathological processes. While traditionally considered separate entities, accumulating evidence suggests that they share common risk factors, such as inflammation and endothelial dysfunction (ED). This review explores the parallels and differences between venous and arterial thrombosis, with particular attention to the role of unprovoked VTE and its potential links to atherosclerosis and systemic inflammation. A key focus is the role of ED, which is emerging as a critical factor in thrombogenesis across both the venous and arterial systems. We examine the current methods for clinically detecting ED, including the use of biomarkers and advanced imaging techniques. Additionally, we discuss novel research avenues, such as the potential of endothelial colony-forming cells and other innovative methodologies, to further unravel the complex mechanisms of thrombosis. Finally, we propose future clinical scenarios where targeting endothelial health could pave the way for more effective prevention and treatment strategies in thrombosis management. Full article
(This article belongs to the Special Issue Novel Insight into Endothelial Function and Atherosclerosis)
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