Special Issue "Insulin-Degrading Enzyme in Health and Disease"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 March 2022) | Viewed by 6256
Interests: diabetes mellitus; insulin resistance; endocrine pancreas; insulin-degrading enzyme
Interests: obesity; diabetes; cardiovascular disease; metabolic syndrome; endocrinology; insulin resistance; insulin clearance; metabolism
Insulin-degrading enzyme (IDE) is an endopeptidase that degrades insulin and amyloid β (Aβ). The Ide gene has been associated with type-2 diabetes mellitus (DM2), and it is a molecular link between DM2 and Alzheimer´s disease (AD). The physiological role(s) of IDE in glucose/insulin homeostasis is very controversial and its potential therapeutic benefit for DM2 and AD remains not completely understood. This Special Issue aims to gather expert articles on the structure, function, and regulation of IDE in physiological and pathophysiological conditions. I therefore invite you to submit original research articles or reviews.
Prof. Dr. Irene Cozar-Castellano
Dr. German Perdomo
Manuscript Submission Information
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- insulin-degrading enzyme
- insulin degradation
- insulin clearance
- Abeta degradation
- diabetes mellitus
- Alzheimer's disease