Host–Microbiome Relationship with Cardiometabolic Disorders

Dear Colleagues,

Thousands of different microbial species inhabit the human body, and they have a strategic role in maintaining host homeostasis. In this context, the gut microbiome is one of the most studied and metabolically dynamic ecosystems known for producing a large and diverse repertoire of small bioactive molecules through the metabolism of dietary or host-derived compounds. For these reasons, the gut microbiome has the potential to exert a strong influence on multiple aspects of our physiology, from energy balance and metabolic regulation to the development and functioning of the immune, endocrine, and nervous systems. Gut microbial dysbiosis has been associated with a higher risk of developing metabolic disorders including cardiovascular disorders, obesity, type 2 diabetes, and nonalcoholic fatty acid disease. However, the mechanisms underlying these connections, as well as the involvement of other microbial ecosystems—besides that of the intestine—still need to be investigated through novel approaches while also targeting the in silico, in vitro, and in vivo functionality of microbes.

This Special Issue “Host-Microbiome Relationship with Cardiometabolic Disorders” will focus on the role of the human microbiome in maintaining host metabolic homeostasis, the mechanisms underlying the breaking of the microbiome–host crosstalk, as well as patient clinical outcomes.

Authors are invited to submit original research and review papers addressing these topics.

Dr. Federica D'Amico
Dr. Davide Agnoletti
Guest Editors

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