Special Issue "Hepatitis B Virus and Host Interactions"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 October 2020).
Interests: host-pathogen interactions; hepatitis B viruses; ESCRT machinery; Rab GTPases; autophagy; intracellular trafficking
The hepatitis B virus (HBV) is an enveloped hepadnavirus that can cause acute and chronic liver inflammation. Persistent HBV infections often result in fatal liver failure and globally rank among the most common infectious diseases, as currently approved therapies are limited and noncurative. The extremely successful spread of this pathogen among humans is explained in part by its effective transmission and replication strategies. Due to the very small genome size, HBV is expected to heavily rely on various host cell functions for survival. For entry and egress, the virus is likely to subvert endocytic, secretory, and exocytic membrane trafficking machineries of the hepatocytes. For productive replication and episomal cccDNA formation, the virus must exploit diverse host factors for its intracellular trafficking, DNA metabolism, and formation of mini-chromosomes. For capsid assembly/disassembly and envelopment, participation of host factors is again essential to the formation of various infectious and non-infectious viral and subviral particles. All of these virus–host interactions contribute to viral persistence and pathogenesis. Although some crucial virus–host interactions have been identified and characterized for HBV, even more remain to be revealed. An improved understanding of host functions regulating the different steps in HBV life cycle may form the basis for novel antiviral therapies.
The aim of this Special Issue of Cells is to highlight recent findings that advance our knowledge about how HBV targets host cell pathways to allow productive infection and establish persistence. We welcome submissions of research papers and reviews that focus on HBV virus–host interactions and will cover topics such as:
- Intracellular trafficking
- cccDNA, mini-chromosome, and persistence
- Assembly, morphogenesis, and egress
- Host-targeting antiviral strategies
Dr. Reinhild Prange
Dr. Chiaho Shih
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- intracellular trafficking
- host-targeting antiviral strategies