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Review

Interplay between Cellular Autophagy and Hepatitis B Virus Replication: A Systematic Review

1
Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing 400016, China
2
Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(9), 2101; https://doi.org/10.3390/cells9092101
Received: 2 July 2020 / Revised: 11 September 2020 / Accepted: 11 September 2020 / Published: 15 September 2020
(This article belongs to the Special Issue Hepatitis B Virus and Host Interactions)
Autophagy, a conserved process in which cells break down and destroy old, damaged, or abnormal proteins and other substances in the cytoplasm through lysosomal degradation, occurs via autophagosome formation and aids in the maintenance of intracellular homeostasis. Autophagy is closely associated with hepatitis B virus (HBV) replication and assembly. Currently, HBV infection is still one of the most serious public health issues worldwide. The unavailability of satisfactory therapeutic strategies for chronic HBV infection indicates an urgent need to elucidate the mechanisms underlying the pathogenesis of HBV infection. Increasing evidence has shown that HBV not only possesses the ability to induce incomplete autophagy but also evades autophagic degradation, indicating that HBV utilizes or hijacks the autophagy machinery for its own replication. Therefore, autophagy might be a crucial target pathway for controlling HBV infection. The definite molecular mechanisms underlying the association between cellular autophagy and HBV replication require further clarification. In this review, we have summarized and discussed the latest findings on the interplay between autophagy and HBV replication. View Full-Text
Keywords: autophagy; hepatitis B virus; viral replication; HBx; HBs; autophagosome autophagy; hepatitis B virus; viral replication; HBx; HBs; autophagosome
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MDPI and ACS Style

Lin, Y.; Zhao, Z.; Huang, A.; Lu, M. Interplay between Cellular Autophagy and Hepatitis B Virus Replication: A Systematic Review. Cells 2020, 9, 2101. https://doi.org/10.3390/cells9092101

AMA Style

Lin Y, Zhao Z, Huang A, Lu M. Interplay between Cellular Autophagy and Hepatitis B Virus Replication: A Systematic Review. Cells. 2020; 9(9):2101. https://doi.org/10.3390/cells9092101

Chicago/Turabian Style

Lin, Yong, Zhenyu Zhao, Ailong Huang, and Mengji Lu. 2020. "Interplay between Cellular Autophagy and Hepatitis B Virus Replication: A Systematic Review" Cells 9, no. 9: 2101. https://doi.org/10.3390/cells9092101

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