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New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation

1
Department of Microbiology and Immunology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
2
Cancer Virology Program, Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
3
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15213, USA
*
Author to whom correspondence should be addressed.
Cells 2020, 9(11), 2430; https://doi.org/10.3390/cells9112430
Received: 12 October 2020 / Revised: 3 November 2020 / Accepted: 4 November 2020 / Published: 6 November 2020
(This article belongs to the Special Issue Hepatitis B Virus and Host Interactions)
The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a genuine cure for HBV. Yet how HBV cccDNA is formed from the viral genomic relaxed circular DNA (rcDNA) and by what host factors had been long-standing research questions. It is generally acknowledged that HBV hijacks cellular functions to turn the open circular DNA conformation of rcDNA into cccDNA through DNA repair mechanisms. With great efforts from the HBV research community, there have been several recent leaps in our understanding of cccDNA formation. It is our goal in this review to analyze the recent reports showing evidence of cellular factor’s involvement in the molecular pathway of cccDNA biosynthesis. View Full-Text
Keywords: hepatitis B virus; replication; covalently closed circular DNA; DNA repair hepatitis B virus; replication; covalently closed circular DNA; DNA repair
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MDPI and ACS Style

Marchetti, A.L.; Guo, H. New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation. Cells 2020, 9, 2430. https://doi.org/10.3390/cells9112430

AMA Style

Marchetti AL, Guo H. New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation. Cells. 2020; 9(11):2430. https://doi.org/10.3390/cells9112430

Chicago/Turabian Style

Marchetti, Alexander L.; Guo, Haitao. 2020. "New Insights on Molecular Mechanism of Hepatitis B Virus Covalently Closed Circular DNA Formation" Cells 9, no. 11: 2430. https://doi.org/10.3390/cells9112430

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