Special Issue "Selected Papers from ‘International Colloquium on Gap Junctions and Cancer’ "

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Motility and Adhesion".

Deadline for manuscript submissions: closed (15 October 2020).

Special Issue Editors

Prof. Marc Mesnil
E-Mail Website1 Website2
Guest Editor
Laboratoire STIM, ERL7003 CNRS-Université de Poitiers, 1 rue G. Bonnet–TSA 51 106, 86073 Poitiers, France
Interests: tumor microenvironment; intercellular communications; gap junction; Connexin43; glioma; cancer cell migration and invasion; exosomes
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Lucia Zaidan Dagli
E-Mail Website
Guest Editor
Laboratory of Experimental and Comparative Oncology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Av. Prof Dr. Orlando Marques de Paiva, 87, CEP 05508900 São Paulo, Brazil
Interests: cancer; carcinogenesis; cancer epidemiology; cancer etiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With very few exceptions (some neurons, red blood cells, spermatozoids, skeletal muscle fibers), all cells of our body are able to exchange cytosolic ions (Na+, K+, Ca2+, etc) and small hydrophilic molecules (for example cAMP, IP3) through particular membrane structures, the gap junctions. These structures are made of transmembrane proteins, called “connexins”, which form intercellular channels permitting the free passage of those ions and molecules (< 1200 Da). The gap junctional intercellular communication appears to be a very fundamental pathway involved in development and many physiological aspects of the organism. Since their description, dysfunction of gap junctions has been shown to be causative of several hereditary human diseases (deafness, skin pathologies, etc.). However, the first pathological process which was associated with a defect of gap junctional intercellular communication was cancer. This correlation was initially observed by Loewenstein and Kanno in liver cancer cells [Intercellular communication and the control of tissue growth: lack of communication between cancer cells, Nature, 116 (1966) 1248-1249]. This germinal work was at the origin of tremendous studies confirming that the lack of gap junctions disturbs tissue homeostasis and favors tumor growth. From this time, the involvement of gap junctions in cancer became more complicated since connexins can either be putative tumor suppressors or pro-invasive factors depending on the stages of tumor progression.

In 2016, we celebrated the 50th anniversary of the germinal work of Loewenstein and Kanno by organizing an “International Colloquium on Gap Junctions and Cancer”, which gathered actors of this field of research at the University of Poitiers (France). Four years after the success of this colloquium, we propose a second edition that will be organized as a collaborative effort between France (University of Poitiers) and Brazil (University of Sao Paulo). This colloquium will present the most recent findings made in the field of gap junctions, connexins, pannexins (connexin-related proteins) and cancer. Basic findings and molecular insights will be key factors for the discovery of possible new cancer approaches. Speakers and attendees are invited to submit research articles or reviews to the special issue of “Cells” dedicated to this colloquium.

Prof. Marc Mesnil
Prof. Maria Lucia Zaidan Dagli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gap junctions
  • connexins
  • pannexins
  • cancer progression
  • cancer invasion
  • cancer therapeutics

Published Papers

There is no accepted submissions to this special issue at this moment.
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