Special Issue "GH and GHR Signaling in Disease and Health"
Deadline for manuscript submissions: 10 July 2021.
Research on the effects of growth hormone (GH) on physiologic processes is generating much debate and controversy. Accumulating evidence supports the direct effects of GH on multiple cell types and tissues, independent of its systemic actions via the GH/IGF1 axis. GH is involved in bone, muscle, and adipose tissue homeostasis, as well as glucose metabolism.
The remarkable longevity and increased healthspan in animal models with GH signaling deficiency, and its protective effects in human patients with GHR mutation against cancer, diabetes, and atherosclerosis have led some to hypothesize that somatopause, or age-related decline in secreted GH, is an evolutionary mechanism defending from age-associated diseases. Based on these observations, GH-related products are being widely marketed as anti-aging therapy and enhancers of athletic performance. However, GH excess alters DNA damage repair, and many animal models with GH overexpression develop neoplasia and have a shorter life span. In cancers, GH excess modifies the tumor microenvironment, promoting chemo- and radiotherapy resistance. These findings highlight potentially adverse risks for GH administration in pituitary-replete adults.
These contrary findings undoubtedly reflect the large variety of molecular and cellular processes affected by GH. A better understanding of the molecular mechanisms driving GH action, as well as elucidation of involved pathways, is critically needed.
This Special Issue is a forum that will bring together a collection of original research articles, reviews, and communications covering any topics related to GH actions, and/or its physiological/pathophysiological roles.
Dr. Vera M. Chesnokova
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- animal models
- metabolic pathways
- GH signaling mutations
- age-related pathologies
- anti-aging therapy
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Authors: Marina Caputo; Emanuela Agosti; Flavia Prodam
Affiliation: Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
2. Title: IGF/GH axis in dento-alveolar complex: from development to aging and therapeutics
Authors: Kouassi Armel Koffi; Sophie Doublier; Jean-Marc Ricort; Sylvie Babajko; Juliane Isaac
Affiliation: Centre de Recherche des Cordeliers, INSERM, Université de Paris, Sorbonne-Université, 15 rue de l’école de médecine, Paris, France
3. Title: Direct and Indirect Actions of GH in Controlling Hepatic Lipid Accumulation
Authors: Rhonda D Kineman; Maria del Carmen Vazquez Borrego; Mercedes Del Rio Morenoet
Affiliation: Jesse Brown VA Medical Center, Research and Development Division, University of Illinois College of Medicine
4. Title: Dynamic regulation of GH-IGF-1 signaling in injury and recovery in hyperoxia-induced neonatal lung injury
Authors: Jasmine Mohr; Christina Vohlen; Alexey Fomenko; Tiffany Grzembke; Rebecca Wilke; Jörg Dötsch; Miguel A. Alejandre-Alcazar
Affiliation: University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), Institut for Lung Health (ILH) Universities of Gießen and Marburg Lung Center (UGMLC), German Center for Lung Research, German
5. Topic: Review on the Hypothalamic GHR-SIRT1 Axis in Aging
Authors: Marianna Sadagurski; Juliana Lima
Affiliation: Department of Biological Sciences, IBio (Integrative Biosciences Center), Wayne State University, Detroit, MI 48202, USA
6. Title: Hormonal signals from the pituitary gland related to running performance in mice
Authors: Christina Walz; Julia Brenmoehl; Andreas Hoeflich
Affiliation: Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Germany