Epithelial Cell Mechanics: From Physiology to Pathology
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Motility and Adhesion".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 75554
Special Issue Editor
Interests: epithelia; cytoskeleton; junctions; mechanobiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epithelia protect the body against external mechanical forces while maintaining a tight barrier to the underlying connective tissue. They have developed a particularly resilient cytoskeleton consisting of interconnected filament networks that are anchored to adhesion sites connecting cells to each other and the extracellular matrix. The resulting transcellular scaffold supports epithelial barrier functions, withstands extreme mechanical deformation, and responds to different mechanical environments through mechanosensing and re-organization. The precise contribution of the different cellular and extracellular matrix components to the overall mechanical properties of epithelial tissues is slowly emerging with the advent of novel tools, software, and image processing routines to study mechanical properties in a vital 3D tissue context.
This current volume aims to present new ideas and novel findings on how mechanical factors determine:
- Epithelial tissue differentiation (e.g., stem cell differentiation, luminogenesis, stratification);
- Epithelial physiology (e.g., ciliary function, single cell extrusion);
- Epithelial wound healing;
- Intraepithelial inflammatory responses;
- Invasion of epithelial cells into the connective tissue compartment;
and how these insights can be exploited to improve epithelial tissue engineering (e.g., the production of functional organoids).
Dr. Rudolf Leube
Guest Editor
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Keywords
- Epithelial mechanobiology
- Cytoskeleton
- Adhesion
- Extracellular matrix
- Tissue engineering
- Mechanical probing
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