Advances in Cellular and Molecular Regulation of Mammalian Meiosis and Other Model Organisms

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 3475

Special Issue Editors


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Guest Editor
1. The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei 230026, China
2. Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China (USTC), Hefei 230026, China
Interests: mammals; gametogenesis; meiosis; meiotic recombination; infertility; genetics; chromosome segregation

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Guest Editor
Life Sciences Institute, Zhejiang University, Hangzhou 310058, China
Interests: mammalian female meiosis; oocyte maturation; mammalian reproductive biology

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Guest Editor
Advanced Medical Research Institute, Shandong University, Jinan 250100, China
Interests: meiosis in yeast and mammals

Special Issue Information

Dear Colleagues,

Meiosis is a specialized form of cell division that is essential for sexual reproduction. During meiosis, gametes with half of chromosome complements of the parental cells are produced through a single round of DNA replication followed by two successive rounds of cell divisions. For successful production of euploid gametes, many unique molecular processes occur in meiosis, specifically the pairing and synapsis of homologous chromosomes, and the formation and repair of programmed DNA double-strand breaks. Chromatin architecture, chromosome movements, gene expression, and epigenetic modifications also show specific features in germ cells. Interestingly, males and females from the same species usually shows substantial differences in meiosis in many aspects, indicating this process is differently modified across the two sexes. Defects in meiosis are the leading cause of primary sterility, spontaneous miscarriages, and congenital disorders. Therefore, understanding the fundamental mechanism underlying the regulation of meiosis is very important, not only for precise diagnosis but also for the development of new strategies to prevent or treat meiotic defects-related diseases.

With the development of cutting-edge technologies and molecular tools, such as super-resolution imaging and single-cell multi-omics, our understanding of meiosis has progressed rapidly.

This Special Issue aims to present the most recent advances in the cellular and molecular regulation of meiosis mainly in mammals and some other model organisms. Original research, review, and mini-review articles that cover, but are not limited to, the following topics are welcome.

Prof. Dr. Qing-Hua Shi
Prof. Dr. Heng-Yu Fan
Prof. Dr. Liangran Zhang
Guest Editors

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Keywords

  • meiosis initiation
  • meiotic recombination
  • chromosomal paring and synapsis
  • chromosome organization and movement
  • chromosome segregation
  • sex body and chromosome inactivation
  • meiosis arrest and resumption
  • pachytene check point
  • transcription and translation regulation
  • genetic and epigenetic regulation
  • meiotic defects related diseases
  • new models or technologies for meiotic studies

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Published Papers (1 paper)

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Review

16 pages, 1265 KiB  
Review
A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development
by Jaroslav Kalous, Daria Aleshkina and Martin Anger
Cells 2023, 12(14), 1830; https://doi.org/10.3390/cells12141830 - 12 Jul 2023
Cited by 10 | Viewed by 3055
Abstract
A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control the nuclear envelope breakdown (NEBD), centrosome [...] Read more.
A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control the nuclear envelope breakdown (NEBD), centrosome maturation, spindle assembly, chromosome segregation, and cytokinesis. In vertebrates, Akt is also an important player during oogenesis and preimplantation development. In the signaling pathways regulating mRNA translation, Akt is involved in the control of mammalian target of rapamycin complex 1 (mTORC1) and thereby regulates the activity of a translational repressor, the eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1). In this review, we summarize the functions of Akt in mitosis, meiosis and early embryonic development. Additionally, the role of Akt in the regulation of mRNA translation is addressed with respect to the significance of this process during early development. Full article
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