Unveiling Axon-Glia Communication in Health and Disease

Dear Colleagues,

The increasing number of non-cell autonomous neurodevelopmental and neurodegenerative disorders pushes the scientific community to improve its current knowledge on intimate and finely regulated time and space connection bridging neurons and glial cells. Indeed, neurons are constantly supported in their life-essential tasks by different glial subtypes on a structural, metabolic and functional level, and in the response to injury. Not surprisingly, dysfunction in this close relationship contributes to neurodevelopment defects and neurodegeneration.

The focus of this Special Issue is to collect a series of original research and reviews updating the many ways by which axons and the different glial subtypes communicate throughout development and adulthood, to maintain or restore central and peripheral homeostasis, and how alterations in this bidirectional communication can contribute to aging and pathology. 

We are confident that this collection will add to our comprehension of different aspects of nervous system physiology and pathology and pave the way for novel therapeutic interventions.

We are looking to explore glia-axon communication in:

• Neurodevelopment;
• Aging;
• Neurodegeneration/Neuroregeneration;
• Enteric nervous system;
• Cancer;
• Pain.

Prof. Michela Rigoni
Dr. Samuele Negro
Guest Editors

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