Special Issue "The Xenobiotic Receptors CAR and PXR in Health and Disease"
Deadline for manuscript submissions: closed (15 September 2020).
Interests: structural biology; protein-protein and protein-ligand interactions; biochemistry; biophysics; nuclear receptors; endocrine disruption
The pregnane X receptor (PXR, NR1I2 according to the official nomenclature) and the constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily acting as ligand-dependent transcription factors. They are both highly expressed in the liver and intestine and play pivotal roles in the protection of the body from a variety of harmful endobiotics and xenobiotics by upregulating genes encoding drug-metabolizing enzymes and transporters. Besides their well-documented role in detoxification, mounting experimental evidence suggests that CAR and PXR control many cellular processes including (patho)physiological responses in energy homeostasis, cell proliferation, inflammation, immune response, metabolic disorders, and cancer development. On the other hand, activation of CAR and PXR has been associated with drug–drug interactions, the deregulation of steroid homeostasis, and chemoresistance. Recent progress in the elucidation of the xenobiotic and non-xenobiotic functions of these receptors can be exploited for further relevant therapeutic applications. This Special Issue of Cells will bring together the most recent advances in the various aspects of the action of CAR and PXR, from basic science to applied therapeutic approaches, and will provide new insights into our understanding of these multifaceted nuclear receptors. Original research or review articles are welcome.
Dr. William Bourguet
Dr. Patrick Balaguer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Endocrine disruption
- Drug-drug interaction
- Structure/function relationships
- Molecular mechanisms